• Research
  • /
  • Neural networks changes in major neurocognitive diseases

Neural networks changes in major neurocognitive diseases


National Brain Research Programme II (2017-1.2.1-NKP-2017-00002

Research leader

Prof. Dr. Anita Kamondi




Major neurocognitive disorders share many similarities, including overlapping clinical symptoms, pathological features and molecular modes of disease transmission. Ongoing studies also suggest that epilepsy may occur in other dementias besides Alzheimer's disease, including frontotemporal

dementia (FTD), Parkinson's dementia (PDD) and diffuse Lewy body dementia (DLB).

Sleep disturbances are also commonly observed in all dementia-related diseases.

zavarokat szintén gyakran észlelnek minden demenciával járó betegségben. A legújabb bizonyítékok arra utalnak, hogy az alvásváltozások szorosan összefügghetnek az

Recent evidence suggests that sleep changes may also be closely related to cognitive decline and the rate of neuronal death.

The prevalence of epileptiform activity and sleep changes are consistent with the modern scientific view of neurocognitive disorders, which describes these diseases as oscillopathies or network diseases. This means that, as the brain's connectivity systems and the neural rhythms that control them gradually change and become inefficient, thinking functions are drastically impaired. Thus, complex neurobiological approaches focusing on altered neural networks may reveal the general mechanisms of functional impairment seen in neurocognitive diseases, and these data may also serve as a potential screening method for early identification of cognitive decline.

The figure below illustrates how the connectivity between brain network nodes responsible for spatial-visual orientation is weakened in patients diagnosed with mild cognitive impairment compared to healthy controls (the red colour in the figure represents the network that is weaker in patients). Data extracted from fMRI research can be used to visualise brain networks and represents a valuable line of research in neurocognitive disorders.

Last updated: 06.06.2021.

Neurocognitive Research Centre

1145 Budapest, Amerikai út 57.


Cookie Policy

© 2021 Neurokognitív Kutatási Központ. All Rights Reserved. Designed by 5mart Studio