Neural networks changes in major neurocognitive diseases
National Brain Research Programme II (2017-1.2.1-NKP-2017-00002
Prof. Dr. Anita Kamondi
Major neurocognitive disorders share many similarities, including overlapping clinical symptoms, pathological features and molecular modes of disease transmission. Ongoing studies also suggest that epilepsy may occur in other dementias besides Alzheimer's disease, including frontotemporal
dementia (FTD), Parkinson's dementia (PDD) and diffuse Lewy body dementia (DLB).
Sleep disturbances are also commonly observed in all dementia-related diseases.
zavarokat szintén gyakran észlelnek minden demenciával járó betegségben. A legújabb bizonyítékok arra utalnak, hogy az alvásváltozások szorosan összefügghetnek az
Recent evidence suggests that sleep changes may also be closely related to cognitive decline and the rate of neuronal death.
The prevalence of epileptiform activity and sleep changes are consistent with the modern scientific view of neurocognitive disorders, which describes these diseases as oscillopathies or network diseases. This means that, as the brain's connectivity systems and the neural rhythms that control them gradually change and become inefficient, thinking functions are drastically impaired. Thus, complex neurobiological approaches focusing on altered neural networks may reveal the general mechanisms of functional impairment seen in neurocognitive diseases, and these data may also serve as a potential screening method for early identification of cognitive decline.
Last updated: 06.06.2021.